Atherosclerosis and Lipid Metabolism

Lipid metabolism by gut microbes and atherosclerosis.

A recent metabolomic study provides evidence that microbial metabolism of lipids in the gut yields product(s) that promote atherosclerosis. These results add another dimension—the microbiome—to the complex determinants of atherogenesis. Atherosclerotic vascular disease is a complex pathophenotype that is governed by genetic and environmental determinants. The mechanistic interplay between speci...

MicroRNAs in lipid metabolism and atherosclerosis.

Numerous studies have examined the role of microRNAs (miRNAs) in cell homeostasis and cardiovascular disease and have markedly improved our understanding of RNA biology in general and the potential role of miRNAs in atherosclerosis. In atherosclerosis, several miRNAs, such as miR-33a,b, miR-92a, miR-126 and others, have been identified that are relevant mediators of pathological processes, incl...

Apolipoprotein CIII and atherosclerosis: beyond effects on lipid metabolism.

The prevailing concept of mechanisms responsible for the development of atherosclerotic lesions largely focuses on the accumulation and retention of low-density lipoproteins in the arterial intima and their subsequent oxidative modification. This oxidation leads to activation of the endothelium, and particularly, expression of adhesion molecules that mediate leukocyte adherence and chemokines w...

Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation

RESULTS The oral administration of rebamipide decreased plaque formation in atherosclerotic lesions as well as the markers of metabolic disorder in ApoE-deficient mice with atherosclerosis. Pro-inflammatory cytokines were also suppressed by rebamapide. In addition, the population of Th17 was decreased, whereas Treg was increased in the spleen of rebamipide-treated ApoE deficient mice. Rebamipid...

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis Running title : FMO 3 modulates TMAO , glucose , lipid metabolism and atherosclerosis